I was able to do some further troubleshooting on this yesterday.
When the two screens are hooked together directly without the hub everything is fine. When the screens are both hooked to the AF-HUB, the issue occurs and if I cycle power to the AF-HUB everything goes back to normal for another 30 minutes or so.
It seems like the AF-HUB is getting into some bad state after a period of time and a power cycle clears it.
Is there any way I can get an AF-HUB to swap out with the one I have to see if the issue goes away? I have the Contemporary Controls EIBA5-100T version of the AF-HUB if that matters.
Thanks!